In 1960, Derbyshire joined the BBC Radiophonic Workshop, a hub for experimental sound design. She quickly became renowned for her technical skill with tape manipulation, oscillators, and early electronic equipment. Her most famous achievement was the 1963 electronic realization of Ron Grainer’s Doctor Who theme, one of the first television themes produced entirely with electronic sounds. It became iconic, though Derbyshire wasn’t fully credited at the time.
Derbyshire mastered musique concrète techniques—(cutting, splicing, and looping magnetic tape), and worked with oscillators, test-tone generators, and found sounds long before synthesizers were common.She collaborated with composers and artists including Brian Hodgson and David Vorhaus (they formed the experimental group White Noise, whose 1969 album An Electric Storm became highly influential). She also worked with electronic avant-garde and even dabbled in psychedelic and pop projects.
She left the BBC in the 1970s, disillusioned with bureaucracy and the commercialization of electronic music, and worked in various roles, including library music and educational sound projects.
In the 1990s, renewed interest in her work arose as electronic musicians (such as The Chemical Brothers, Aphex Twin, and Orbital) cited her as an influence.